As the Omicron variant ravages the country, we begin the New Year with a resigned realization that COVID is likely a part of our lives forever. We are vaxxed, masked, tested, distanced, and saddened by our shocking loss of loved ones! We are resolved to finally move beyond and pursue a new post-COVID normal, practice appropriate ongoing caution, and expect additional hardships. But we are also determined to return to our routines and again embrace aspirations, interactions, and the business of fulfilling lives. Although COVID will still be with us this year, Americans are poised for the pandemic to become endemic!